May peace and blessings be on all the Messengers of God. Prophet Muhammad is a direct descendant of Isma’il, the first son of Prophet Ibrahim(Abraham). Prophet Muhammad was born in Makkah as a fullfilment of the prayer of Abraham as explained in the following verses of the Holy Quran, a book of revelations from God to the Prophet. 
002.124 And remember that Abraham was tried by his Lord with certain commands, which he fulfilled: He said: “I will make thee an Imam to the Nations.” He pleaded: “And also (Imams) from my offspring!” He answered: “But My Promise is not within the reach of evil-doers.”
002.125 Remember We made the House a place of assembly for men and a place of safety; and take ye the station of Abraham as a place of prayer; and We covenanted with Abraham and Isma’il, that they should sanctify My House for those who compass it round, or use it as a retreat, or bow, or prostrate themselves (therein in
prayer).
002.126 And remember Abraham said: “My Lord, make this a City of Peace, and feed its people with fruits,-such of them as believe in God and the Last Day.” He said: “(Yea), and such as reject Faith,-for a while will I grant them their pleasure, but will soon drive them to the torment of Fire,- an evil destination (indeed)!”